abstract：:Healing rates were examined retrospectively in 124 outpatients with peptic ulcer who had received cimetidine for at least four weeks. Treatment was unsuccessful in 73 patients. A statistical analysis of the factors involved in treatment failure revealed that in patients with duodenal ulcers 60.6% of the treatment succ...

journal_title：Clinical therapeutics

authors： Granelli P,Angelini GP,Celli L

更新日期：1984-01-01 00:00:00

abstract：:Flecainide, a new antiarrhythmic agent, was given to eight healthy men to ascertain plasma drug levels and to assess tolerance for the drug. Each subject received a single intravenous (IV) dose (0.5, 1, 1.5, or 2 mg/kg) of flecainide, and plasma levels of unchanged flecainide were measured by gas-liquid chromatography...

journal_title：Clinical therapeutics

authors： Conard GJ,Carlson GL,Frost JW,Ober RE,Leon AS,Hunninghake DB

更新日期：1984-01-01 00:00:00

abstract：:Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. It has been the subject of more than 8,000 published papers, which include clinical reports of its usefulness in approximately 100 diseases and symptoms. In the United States the only indications for use in the official labelin...

journal_title：Clinical therapeutics

authors： Finkel MJ

更新日期：1984-01-01 00:00:00

abstract：:A recent report of two isolates of Streptococcus bovis resistant to killing by low levels of penicillin G prompted this study of the in vitro susceptibility of 100 clinical isolates of S bovis to six antibiotics. Using a microdilution method, we found the minimum bactericidal concentrations for 99% of the isolates to ...

journal_title：Clinical therapeutics

authors： Klein RS,Milazzo JJ,Edberg SC

更新日期：1984-01-01 00:00:00

abstract：:Lidocaine generally is the agent of first choice against acute ventricular arrhythmias arising from many causes. It is clinically effective and well tolerated, having a rapid onset of action and a favorable electrophysiological profile. Unlike other antiarrhythmic agents, lidocaine does not interact with the autonomic...

journal_title：Clinical therapeutics

authors： Anderson JL

更新日期：1984-01-01 00:00:00

abstract：:The effects of long-term aprindine administration on cardiac function were clinically investigated in seven patients with supraventricular or ventricular arrhythmias associated with organic heart disease. Three patients had normal cardiac function and four had various degrees of cardiac dysfunction before treatment wi...

journal_title：Clinical therapeutics

authors： Tsutsui H,Araki H,Nagata Y,Nakamura M

更新日期：1984-01-01 00:00:00

abstract：:The acid-neutralizing capacity and sodium content of nine antacid products available in Belgium were evaluated and compared with typical values for Mylanta-II. Liquid and tablets of Mylanta-II have a higher acid-neutralizing capacity per unit dose than do all the other Belgian antacids tested. On a unit dose basis, th...

journal_title：Clinical therapeutics

authors： Gombatz VW

更新日期：1984-01-01 00:00:00

abstract：:Basic research in the neurosciences has led to a theory of opiate withdrawal involving endogenous opioid peptides and hyperactive norepinephrine neurons. This theory predicts the efficacy of clonidine, a nonopiate agent, in the management of opiate withdrawal. Clonidine, which offers numerous advantages over methadone...

journal_title：Clinical therapeutics

authors： Gold MS,Dackis CA

更新日期：1984-01-01 00:00:00

abstract：:A total of 804 pediatric patients (572 neonates and 232 infants and children) with suspected or documented serious infections were enrolled in a multicenter open study of netilmicin, a new semisynthetic aminoglycoside. All patients were evaluable for safety; 161 (20%) had bacteriologically documented infections and we...

journal_title：Clinical therapeutics

authors： Chiu TA,Ayoub EM,Lorber RR,Danzig MR,Norred S

更新日期：1983-01-01 00:00:00

abstract：:Etodolac, aspirin, and placebo were evaluated for efficacy and safety in 18 patients with adult-onset, active rheumatoid arthritis. This was a 12-week, double-blind, parallel-group study divided into drug titration and maintenance periods and preceded by a washout period of up to two weeks. The mean daily maintenance ...

journal_title：Clinical therapeutics

authors： Edwards W

更新日期：1983-01-01 00:00:00

abstract：:Several patients treated with amoxapine (in dosages ranging from 50 to 300 mg/day) had excellent initial responses followed by relapse unresponsive to dose adjustment, suggesting pharmacological tolerance to its antidepressant effect. ...

journal_title：Clinical therapeutics

authors： Zetin M,Aden G,Moldawsky R

更新日期：1983-01-01 00:00:00

abstract：:Thirty children with serious gram-negative infections were treated with either netilmicin, 2 mg/kg, or tobramycin, 1 mg/kg, every eight hours for a minimum of 72 hours. Because of the administration of different doses, a "blind" investigator evaluated treatment response while another investigator adjusted the doses on...

journal_title：Clinical therapeutics

authors： Weippl G

更新日期：1983-01-01 00:00:00

abstract：:Steady-state bioavailability of a sustained-release quinidine gluconate formulation was compared with that of a sustained-release quinidine sulfate preparation in a crossover study. Sixteen healthy men were given multiple doses (two tablets every 12 hours) of the two drugs in randomized sequence. Blood samples were ob...

journal_title：Clinical therapeutics

authors： Taggart WV,Holyoak W

更新日期：1983-01-01 00:00:00

abstract：:Quinfamide, a luminal amebicide, is a dichloroacetyl quinolol used to treat chronic and subacute intestinal amebiasis. Several previous dose-ranging studies have indicated that quinfamide is effective in a total dose of 300, 600, or 1,200 mg. The present study was undertaken to determine the efficacy of 100- and 200-m...

journal_title：Clinical therapeutics

authors： Guevara L,Garcia Tsao G,Uscanga LF

更新日期：1983-01-01 00:00:00

abstract：:Absorption of the antiarrhythmic agent mexiletine from conventional capsules (200 mg) and two sustained-release formulations (360 and 432 mg) was studied in four healthy volunteer subjects, and use of the 360-mg preparation was studied in nine patients who had been using conventional capsules. In the four volunteers, ...

journal_title：Clinical therapeutics

authors： Holt DW,Chadwick DE,Campbell RW

更新日期：1983-01-01 00:00:00

abstract：:Cefoperazone was evaluated as the therapeutic agent in 64 adults with serious infections. Included were pneumonias, urinary tract infections, septicemia, osteomyelitis, joint infections, and superficial infections. A total of 84 organisms, including many multiantibiotic-resistant strains, were designated as the etiolo...

journal_title：Clinical therapeutics

authors： Temple J,Mogabgab WJ

更新日期：1982-01-01 00:00:00

abstract：:Twenty-four patients with pulmonary infections (7 pneumoniae, 17 exacerbations of chronic bronchitis) were treated with a combination of 250 mg of amoxicillin and 125 mg of clavulanic acid supplemented by 500 mg of amoxicillin every eight hours. All patients showed good clinical, roentgenological, and bacteriological ...

journal_title：Clinical therapeutics

authors： Saroglou G,Paniara-Volika O,Sima A,Paraskevopoulou E,Makris G,Hatzimichelakis N,Vassilopoulos N,Kontomichalou P

更新日期：1982-01-01 00:00:00

abstract：:A phase II study of weekly low-dose doxorubicin (6 to 12 mg/m2) showed it to be an effective, well-tolerated therapy in advanced breast cancer. Although most of the 34 patients studied had been clinically resistant to previous endocrine measures and/or other kinds of chemotherapy, had a median score of 60 on Karnofsky...

journal_title：Clinical therapeutics

authors： Mattsson W,Borgström S,Landberg T

更新日期：1982-01-01 00:00:00

abstract：:One hundred fourteen women undergoing vaginal hysterectomy (n = 63) or abdominal hysterectomy (n = 51) were randomly allocated to one of three groups: regimen 1--cefotaxime perioperatively; regimen 2--cefotaxime perioperatively and for 24 hours postoperatively; or regimen 3--cefazolin perioperatively and for 24 hours ...

journal_title：Clinical therapeutics

authors： Roy S,Wilkins J

更新日期：1982-01-01 00:00:00

abstract：:A single-blind comparison was undertaken to evaluate 250 mg of cinoxacin and 100 mg of nitrofurantoin, both drugs being given four times a day, for the treatment of urinary tract infections. Complete data are available from 58 patients, most of whom were treated for 10 to 15 days. The clinical response was similar in ...

journal_title：Clinical therapeutics

authors： Schneider RE

更新日期：1982-01-01 00:00:00

abstract：:A total of 128 corticosteroid-independent adults with chronic allergic asthma were treated for six weeks with 400 micrograms/day of beclomethasone dipropionate aerosol. Most patients (114 or 89%) had a good to excellent response, characterized by a marked improvement in the signs and symptoms of asthma. Substantial im...

journal_title：Clinical therapeutics

authors： Malfitan VA

更新日期：1982-01-01 00:00:00

abstract：:A benzothiazepine derivative, CRD-401, was administered orally in a dosage of 60 to 120 mg/day to 14 patients with various renal diseases. The systolic pressure was lowered slightly in some cases after administration of CRD-401. Urine volume and urinary excretion of electrolytes were increased by the drug in most pati...

journal_title：Clinical therapeutics

authors： Funyu T,Nigawara K,Ohno K,Hamada W,Yagihashi Y

更新日期：1981-01-01 00:00:00

abstract：:Cefoperazone, a third-generation cephalosporin derivative, has been reported to have excellent antibacterial activity against a wide range of gram-positive and gram-negative pathogens, including Pseudomonas aeruginosa. We treated 54 patients with a variety of clinical infections with cefoperazone and determined the su...

journal_title：Clinical therapeutics

authors： Sarver DK,Christensen GD,Hester MG,Ling FW,Pate JW,Rosenberg EW,Anderson GD,Bisno AL

更新日期：1981-01-01 00:00:00

abstract：:Eleven patients suffering from WHO stage II essential arterial hypertension were treated with the combination of labetalol plus chlorthalidone in the reciprocal ratio of 10:1 in the form of once-a-day administration in the morning. The dosage was individualized on the basis of hypotensive response and side effects unt...

journal_title：Clinical therapeutics

authors： Rossi AG

更新日期：1981-01-01 00:00:00

abstract：:In a double-blind factorial clinical trial in 300 patients (150 primiparae and 150 multiparae), the effects of amniotomy, rociverine, and butylscopolamine bromide administration on the course of labor were investigated. Rociverine significantly reduced the dilatation time and had no effect on the delivery time. Butyls...

journal_title：Clinical therapeutics

authors： Guerresi E,Gori G,Beccari A,Farro M,Mazzanti C

更新日期：1981-01-01 00:00:00

abstract：:Long-term safety and efficacy of feprazone (4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione), an antirheumatic drug that is well tolerated in the gastrointestinal tract, were assessed in a noncontrolled multicenter trial. Administered at a daily dosage of 600 mg for a mean duration of 114.1 days, feprazone was well tolera...

journal_title：Clinical therapeutics

authors： Bianchi G,Cerri B,Grasso S,Carazzi R,Dotti F,Ongari R,Cerrato O,Viara M

更新日期：1981-01-01 00:00:00

abstract：:A double-blind, randomized protocol was used to investigate the activity of a benzodiazepine derivative, chlordesmethyldiazepam, at two different dosages, 1 mg and 2 mg (CDDZ1 and CDDZ2), on mnestic functions and information processing in normal subjects. CDDZ2 significantly impaired short-term shortage of logical and...

journal_title：Clinical therapeutics

authors： Scarone S,Strambi LF,Cazzullo CL

更新日期：1981-01-01 00:00:00

abstract：:A multicenter, double-blind clinical evaluation of three formulations of betamethasone dipropionate was conducted in 258 patients with severe psoriasis. The results obtained after a standard two-week treatment period clearly indicated that a new glycol preparation produced significantly greater improvement than the oi...

journal_title：Clinical therapeutics

authors： Leer JA Jr

更新日期：1980-01-01 00:00:00

abstract：:A 28-day, double-blind study involving 56 outpatients ws initiated to compare the anxiolytic efficacy and safety of ketazolam once a day at bedtime (HS) with diazepam given three times a day (TID) and placebo HS or TID. Ketazolam HS was at least equivalent, and in some respects superior, to diazepam TID with fewer, le...

journal_title：Clinical therapeutics

authors： Kim KK,Sirman A,Trainor FS,Lee BY

更新日期：1980-01-01 00:00:00

abstract：:Allylestrenol was used to treat 375 women with threatened pregnancies. Results show that this drug is capable of maintaining pregnancy in a large series of ambulant patients and is safe for both mother and child. Allylestrenol does not maintain pregnancy if placental dysfunction is present, however. Newborns whose mot...

journal_title：Clinical therapeutics

authors： Cortés-Prieto J,Bosch AO,Rocha JA

更新日期：1980-01-01 00:00:00

abstract：:Fifty clinic patients with mild to moderately severe dermatoses were treated for three weeks with bufexamac, a hydroxamic acid compound with anti-inflammatory properties. Half the patients had either contact or seborrheic dermatitis; the remaining 25 were distributed among five other diagnostic categories. Evaluation ...

journal_title：Clinical therapeutics

authors： Solano E

更新日期：1980-01-01 00:00:00